Drugs that impair microtubule dynamics alter microtubule-kinetochore attachment and invoke the mitotic checkpoint which arrests cells in mitosis.The arrest can last for hours, but it is leaky: cells adapt (i.e., slip out of it) and exit from mitosis.Here, we investigate the mechanism that allows cells to escape, and whether it is possible to preven
Abstract Background Solid organ transplant recipients show heterogeneity in the occurrence and timing of acute rejection episodes.Understanding the factors responsible for such variability in patient outcomes may lead to improved diagnostic and therapeutic approaches.Rejection kinetics of transplanted organs mainly depends on the extent of genetic
Background: Pulmonary arterial hypertension Girls Hats (PAH) is a disease characterized by increased pulmonary vascular resistance (PVR).Pregnancy in the setting of PAH is associated with significant maternal morbidity and mortality, typically present during labor and the early postpartum.Historically, observed maternal mortality has been as high a
The study investigates the two different underlying ablation mechanisms Faux Tweed Coats of WS2 processed by femtosecond (fs) laser with different fluences.With increasing fluence, the saturable expansion of craters and the transformation of three distinct crater morphologies are found.The material response and the transfer and deposition of laser
The objective of this study is: 1) to obtain information in relation to the implementation of instructional model of integrated social science Medical and Ambulatory supplies / Clinical Laboratory at Junior Secondary School in Surakarta City; 2) to identify the inhibiting factors; and 3) to know some efforts performed by Social Science teachers to